67806
Rhodol
≥85% (HPCE)
Synonym(s):
3′-Amino-6′-hydroxy-fluoran
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About This Item
Empirical Formula (Hill Notation):
C20H13NO4
CAS Number:
Molecular Weight:
331.32
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
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assay
≥85% (HPCE)
fluorescence
λex 492 nm; λem 516 nm in 0.1 M phosphate pH 7.0
storage temp.
2-8°C
SMILES string
Nc1ccc2c(Oc3cc(O)ccc3C24OC(=O)c5ccccc45)c1
InChI
1S/C20H13NO4/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,22H,21H2
InChI key
OKFGUUIODGPPLE-UHFFFAOYSA-N
Application
Rhodol and its derivatives may be used in a wide variety of molecular imaging and immunofluorescence microscopy applications. Specific Rhodol derivatives are useful as enzyme substrates.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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J E Whitaker et al.
Analytical biochemistry, 207(2), 267-279 (1992-12-01)
A series of chemically reactive, fluorescent rhodol derivatives was prepared and evaluated. Reactive functional groups included activated esters, amines, haloacetamides, fixable hydrazide derivatives, acrylamides, and photoaffinity reagents. Depending on the choice of substituents, absorption maxima of the dyes varied from
M Benchaib et al.
Histochemistry and cell biology, 106(2), 253-256 (1996-08-01)
Fluorescein isothiocyanate (FITC) is largely used in immunofluorescence methods. We propose to analyse the quality of some recent fluorochromes using image analysis. Fluorochromes tested include FITC and dichlorotriazinylaminofluorescein (DTAF), dipyrrometheneboron difluoride (BODIPY), Rhodol Green and cyanine 2. RAMOS cells were
Tao Peng et al.
Organic letters, 12(3), 496-499 (2010-01-14)
A highly efficient and concise synthetic scheme for rhodol fluorophores is developed with palladium-catalyzed amination reaction as the key step. This new synthetic route is utilized to construct a rhodol library, potentially useful for the design of novel fluorescent probes.
Raphael Alford et al.
Molecular imaging, 8(6), 341-354 (2009-12-17)
Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be investigated before they can be administered safely to
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