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53728

Sigma-Aldrich

Hyaluronic acid sodium salt from bovine vitreous humor

lyophilized

Synonym(s):

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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About This Item

Linear Formula:
(C14H21NaNO11)n
CAS Number:
9067-32-7
MDL number:
MFCD01773053
UNSPSC Code:
12352201

form

solid

quality

lyophilized

solubility

0.3 M phosphate buffer, pH 5.35: 0.3 mg/mL, clear, colorless (gentle heating)

storage temp.

−20°C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

InChI key

YWIVKILSMZOHHF-QJZPQSOGSA-N

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Application

Hyaluronic acid is used in the preparation of viscosupplements for the treatment of conditions such as osteoarthritis and for the development of vitreous replacement gels. Hyaluronic acid is also used in studies of wound repair and as a possible modulator of stem cell growth and differentiation.

Other Notes

Sales restrictions may apply

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Teri T Kleinberg et al.
Survey of ophthalmology, 56(4), 300-323 (2011-05-24)
Vitreoretinal disorders constitute a significant portion of treatable ocular disease. Advances in vitreoretinal surgery have included the development and characterization of suitable substitutes for the vitreous. Air, balanced salt solutions, perfluorocarbons, expansile gases, and silicone oil serve integral roles in
Paul H Wooley et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 100(3), 808-816 (2012-02-11)
The objective of this study was to evaluate and compare the biocompatibility profiles of hyaluronic acid (HA) viscosupplements from avian and non-mammalian sources. Inflammatory and immune reactions were assessed in models of both clinically relevant and stringent immunological exposure conditions.
Towards an ideal biomaterial for vitreous replacement: Historical overview and future trends.
Baino F.
Acta Biomaterialia, 7, 9210935-9210935 (2011)
Mitsuhiko Sato et al.
Arthritis research & therapy, 14(1), R31-R31 (2012-02-09)
Mesenchymal stem cells (MSCs) can differentiate into various connective tissue cells. Several techniques have been used for the clinical application of MSCs in articular cartilage repair; however, there are many issues associated with the selection of the scaffold material, including
A J Bagherpoor et al.
TSitologiia i genetika, 44(6), 15-21 (2011-01-22)
Two main characteristics of all types of stem cells are their potency for differentiation and self renewal capacity. There is a lot of interest to find the conditions and factors, which govern these behaviours of stem cells. It is very
View All Related Papers

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