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464R-1

Sigma-Aldrich

LIN28 (EP150) Rabbit Monoclonal Primary Antibody

Synonym(s):

LIN-28

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP150, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (464R-14)
vial of 0.1 mL concentrate Research Use Only (464R-14-RUO)
vial of 0.5 mL concentrate (464R-15)
vial of 1.0 mL concentrate (464R-16)
vial of 1.0 mL concentrate Research Use Only (464R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (464R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (464R-17)
vial of 7.0 mL pre-dilute ready-to-use (464R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (464R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

dysgerminoma, embryonal carcinoma, seminoma, yolk sac tumor

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, nuclear

Gene Information

human ... LIN28A(79727)

General description

LIN-28 is a RNA-binding protein that acts as an inhibitor of let-7 tumor suppressor microRNAs, and posttranscriptional regulator of mRNAs involved in the renewal and development of embryonic stem cells.[1][2][3][4][5] Anti-LIN28 reactivity is seen in extragonadal seminomas/germinomas, embryonal carcinoma, teratomas, and yolk sac tumors. Anti-LIN28 reactivity is only seen in a small fraction of various extragonadal-non-germ cell tumors, and adult testis tissues. Therefore, Anti-LIN28 is a useful marker in the differential identification of germ cell tumors and cancers of non-germ cell origin.[6][7][8][9][10][11][12]

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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A J M Gillis et al.
International journal of andrology, 34(4 Pt 2), e160-e174 (2011-06-03)
OCT3/4, NANOG, SOX2 and, most recently, LIN28 have been identified as key regulators of pluripotency in mammalian embryonic and induced stem cells, and are proven to be crucial for generation of the mouse germ-cell lineage. These factors are a hallmark
Hao Zhu et al.
Cell, 147(1), 81-94 (2011-10-04)
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both
Shuping Peng et al.
Stem cells (Dayton, Ohio), 29(3), 496-504 (2011-03-23)
Lin28 inhibits the expression of let-7 microRNAs but also exhibits let-7-independent functions. Using immunoprecipitation and deep sequencing, we show here that Lin28 preferentially associates with a small subset of cellular mRNAs. Of particular interest are those for ribosomal proteins and
Dengfeng Cao et al.
Human pathology, 42(5), 710-718 (2011-02-04)
LIN28 is an RNA-binding protein involved in maintaining the pluripotency of embryonic stem cells. Using formalin-fixed, paraffin-embedded tissue blocks, we performed immunohistochemical staining of LIN28 in 103 primary and 81 metastatic testicular germ cell tumors (54 intratubular germ cell neoplasias
Francisco F Nogales et al.
Histopathology, 65(1), 51-59 (2014-01-22)
To establish a diagnostic immunohistochemical panel for various histotypes of yolk sac (primitive endodermal) tumours (YSTs) by comparison with the human yolk sac (HYS) immunophenotype. Twenty-five YSTs showing either classical patterns (CPs) of histology (microcystic/reticular, n = 14; polyvesicular, n
View All Related Papers

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