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450R-1

Sigma-Aldrich

Prostein (EP381) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP381, monoclonal

description

This product is intended for research use only. Not for use in diagnostic procedures.

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate Research Use Only (450R-14-RUO)
vial of 1.0 mL concentrate Research Use Only (450R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (450R-17-RUO)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (450R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

prostate, prostate carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

Prostein is a type IIIA transmembrane protein comprising a cleavable signal peptide and 11 transmembrane domains. In vitro studies demonstrate that prostein transcription and expression is androgen responsive. Prostein expression was found to be restricted to tissues of prostatic origin such as non-neoplastic prostate, prostate lesions, and malignant prostate tissues. Due to its high specificity, immunohistochemical detection of prostein may have utility in distinguishing prostatic carcinoma from the carcinomas of bladder, kidney, lung and colorectum.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

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Todd Sheridan et al.
The American journal of surgical pathology, 31(9), 1351-1355 (2007-08-28)
Adenocarcinoma of the prostate can present as metastatic carcinoma with no known primary. Prostatic origin can be confirmed in most of these cases by immunohistochemistry for prostate-specific antigen (PSA) and prostate-specific acid phosphatase. In a small subset of high-grade prostate
Michael Kalos et al.
The Prostate, 60(3), 246-256 (2004-06-04)
Prostein is a recently described molecule expressed at the mRNA level in a prostate-specific manner. A murine monoclonal antibody was developed, characterized, and used to evaluate the expression of prostein protein in prostatic, other normal tissue and tumor samples. The
J Xu et al.
Cancer research, 61(4), 1563-1568 (2001-03-14)
In this report, we describe the application of a systematic, genome-based approach to identify prostein, a novel prostate-specific protein expressed in normal and malignant prostate tissues. Characterization of the prostein gene shows that prostein cDNA encodes a 553-amino acid protein.

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