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445R-1

Sigma-Aldrich

NKX2.2 (EP336) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP336, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (445R-14)
vial of 0.1 mL concentrate Research Use Only (445R-14-RUO)
vial of 0.5 mL concentrate (445R-15)
vial of 1.0 mL concentrate (445R-16)
vial of 1.0 mL concentrate Research Use Only (445R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (445R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (445R-17)
vial of 7.0 mL pre-dilute ready-to-use (445R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (445R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

Ewing’s sarcoma, pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Related Categories

General description

NKX2.2 is a homeodomain transcription factor that plays a role in neuroendocrine and glial differentiation. NKX2.2 is upregulated in Ewing′s sarcoma as a result of the oncogenic EWS-FLI1 fusion protein. As one of many small round blue cell tumors, Ewing′s sarcoma can be difficult to diagnose due to the characteristic undifferentiated morphology. NKX2.2 has proven its utility as a sensitive maker for distinguishing Ewing′s sarcoma from other round blue cell tumors when used in a panel.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Arvind Rajwanshi et al.
Journal of cytology, 26(1), 1-10 (2009-01-01)
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells. They generally include Ewing's sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms' tumor. Other differential diagnoses of small round
Yoshinari Yamamoto et al.
Journal of cytology, 32(1), 30-32 (2015-05-08)
Renal Ewing sarcoma (ES) is a rare malignant tumor characterized by fusion of the EWSR1 gene with a member of the ETS family of oncogenes, arising at a specific chromosomal translocation. Diagnosis of ES can be problematic, especially from cytological
Yin P Hung et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(4), 370-380 (2016-02-06)
Ewing sarcoma shows considerable histologic overlap with other round cell tumors. NKX2-2, a homeodomain transcription factor involved in neuroendocrine/glial differentiation and a downstream target of EWSR1-FLI1, has been reported as an immunohistochemical marker for Ewing sarcoma. We assessed the specificity
Richard Smith et al.
Cancer cell, 9(5), 405-416 (2006-05-16)
Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By
Akihiko Yoshida et al.
The American journal of surgical pathology, 36(7), 993-999 (2012-03-27)
Ewing sarcoma is a high-grade round cell sarcoma that affects bones and soft tissues in children and young adults. Its diagnosis can be challenging, and the differential diagnoses include a wide variety of small round cell tumors. CD99 and FLI-1

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