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43381

Sigma-Aldrich

(S)-Sodium 2,3-dihydroxyisovalerate hydrate

≥95.0% (CE)

Synonym(s):

(S)-2,3-Dihydroxy-3-methylbutanoic acid sodium salt, L(+)-α,β-Dihydroxyisovaleric acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C5H10O4
Molecular Weight:
134.13
Beilstein/REAXYS Number:
4657323
MDL number:
MFCD18452829
UNSPSC Code:
12352200
PubChem Substance ID:
329756339

Quality Level

100

assay

≥95.0% (CE)

optical purity

enantiomeric excess: ≥98.0%

storage temp.

2-8°C

SMILES string

O.[Na+].CC(C)(O)[C@H](O)C([O-])=O

InChI

1S/C5H10O4.Na.H2O/c1-5(2,9)3(6)4(7)8;;/h3,6,9H,1-2H3,(H,7,8);;1H2/q;+1;/p-1/t3-;;/m1../s1

InChI key

KGRRZNPTTZIUMS-HWYNEVGZSA-M

Application

Sodium 2,3-dihydroxyisovalerate hydrate may be used to study the distribution, function and kinetics of dihyroxy-acid dehydratases such as the superoxide-sensitive enzyme α, β-dihydroxyisovalerate dehydratase.

Biochem/physiol Actions

Metabolite in the pantothenate and CoA biosynthesis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBD1064V
BCBD1064

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C F Kuo et al.
The Journal of biological chemistry, 262(10), 4724-4727 (1987-04-05)
Increasing the intracellular flux of O-2 by incubating aerobic Escherichia coli with paraquat or plumbagin markedly lowered the alpha, beta-dihydroxyisovalerate dehydratase activity detectable in extracts from these cells. This effect was not seen in the absence of dioxygen and was
O R Brown et al.
Archives of biochemistry and biophysics, 319(1), 10-22 (1995-05-10)
Dihydroxy-acid dehydratase (DHAD) has a [4Fe-4S] cluster and is reported to be facilely inactivated by oxidant stress. To directly assess the biological effects in vivo of superoxide dismutase (SOD) on the oxidant sensitivity of DHAD, we used an Escherichia coli
Concepts and perspectives in enzyme stereochemistry.
K R Hanson
Annual review of biochemistry, 45, 307-330 (1976-01-01)

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