423M-1

Transgelin (2A10C2) Mouse Monoclonal Antibody

• UNSPSC Code: 12352202
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: 2A10C2, monoclonal
• description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (423M-14); vial of 0.5 mL concentrate (423M-15); bottle of 1.0 mL predilute (423M-17); vial of 1.0 mL concentrate (423M-16); bottle of 7.0 mL predilute (423M-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• isotype: IgG1
• control: leiomyoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic
• Gene Information: human ... TAGLN(6876)

Description

General description

Transgelin is a shape change sensitive 22-25 kDa actin cross-linking/gelling protein of the calponin family localized to the cell membrane and cytoplasm as a novel regulator of MMP-9 expression.¹ Recent evidence suggests that transgelin may act as a tumor suppressor; for example, expression can be lost in prostate, breast and colon cancers which is consistent with suppression of the metallo matrix protease-9 (MMP-9) by transgelin, whereas MMP-9 is upregulated in these common cancers.¹ This protein is ubiquitous to vascular and visceral smooth muscle and is considered an early marker of smooth muscle differentiation and may be an early and sensitive marker for the onset of transformation.² Transgelin can be found in fibroblasts, smooth muscle and some epithelium where expression is likely driven by TGF-beta1. ³ In some cases differentiating smooth muscle within malignant lesions can be challenging, therefore use of myogenic markers such as transgelin may serve to define smooth muscle differentiation in soft tissue tumors.^1-3

Quality

IVD

IVD

IVD

RUO

Linkage

Transgelin Positive Control Slides, Product No. 423S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany