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409R-1

Sigma-Aldrich

Thyroid Peroxidase (EP159) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352202

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP159, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (409R-14)
vial of 0.5 mL concentrate (409R-15)
bottle of 1.0 mL predilute (409R-17)
vial of 1.0 mL concentrate (409R-16)
bottle of 7.0 mL predilute (409R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

papillary thyroid carcinoma, thyroid

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... TPO(7173)

General description

Difficulties in the diagnosis of thyroid lesions, even with histologic analysis, are well recognized.[1][2] Diagnostic discrepancies in follicular thyroid carcinoma and papillary carcinoma have been considered to be a challenge among pathologists for a long time.[1][2] These diagnostic challenges have inspired clinical research interests in novel methods of correctly identifying thyroid lesions.[3] Thyroid peroxidase (TPO) is a thyroid-specific enzyme involved in the synthesis of thyroid hormone. TPO can be detected in formalin-fixed, paraffin-embedded tissues of normal thyroid, thyroid carcinoma of papillary and follicular type.[3][4][5] Depending on different series of studies, the sensitivity of TPO for carcinoma of the thyroid has been reported between 44% and 100%, while specificity ranges between 68% and 100%.[3][4][5] Studies indicate that anti-thyroid peroxidase, anti-HBME-1, anti-galectin-3, and anti-CK19, together may form a useful immunohistochemical panel for identification of thyroid carcinoma of papillary and follicular types.[3][4][5]

Quality


IVD
IVD
IVD
RUO

Linkage

Thyroid Peroxidase Positive Control Slides, Product No. 409S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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U Yousaf et al.
Clinical endocrinology, 68(6), 996-1001 (2007-11-23)
Cold thyroid nodules are common, in particular in iodine-deficient areas, but only a minority of them are malignant requiring surgery. Thyroid peroxidase (TPO) immunostaining of fine-needle aspiration cytology (FNAC) material has proven helpful in diagnosing cells from malignant lesions, but
Brigitte Franc et al.
Human pathology, 34(11), 1092-1100 (2003-12-04)
We evaluated the interobserver and intraobserver reproducibility in the histopathology of follicular thyroid carcinoma (FTC). Forty-one anonymous FTC pathology slides were independently reviewed by 5 pathologists, and 31 of them were also evaluated twice by the same pathologist. A final
Ivan Paunovic et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(5), 368-379 (2012-04-21)
We evaluated some proposed molecular thyroid tumor markers: thyroid peroxidase (TPO), galectin-3, cytokeratin-19, and HBME-1, individually and in combination, by immunohistochemistry in a total of 242 archival thyroid tissue sections. The expression of each individual marker was most helpful for
Katie B Weber et al.
American journal of clinical pathology, 122(4), 524-531 (2004-10-19)
In this retrospective histologic study, galectin-3 had a sensitivity of 92% (22/24) for papillary thyroid carcinoma and 44% (4/9) for follicular thyroid carcinoma. Thyroid peroxidase (TPO) had a sensitivity of 50% (12/24) for papillary and 11% (1/11) for follicular carcinoma.
Svetlana Savin et al.
Human pathology, 39(11), 1656-1663 (2008-07-29)
Thyroperoxidase and galectin-3 have been reported as useful immunohistochemical markers of thyroid malignancy. In this study, we evaluated the relationship between immunohistochemical staining results for these markers and clinicopathologic features of patients with differentiated thyroid cancer. A total of 193
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