Journal of controlled release : official journal of the Controlled Release Society, 164(3), 331-337 (2012-07-18)
The mechanism behind the immunostimulatory effect of the cationic liposomal vaccine adjuvant dimethyldioctadecylammonium and trehalose 6,6'-dibehenate (DDA:TDB) has been linked to the ability of these cationic vesicles to promote a depot after administration, with the liposomal adjuvant and the antigen
The journal of physical chemistry. B, 116(30), 9269-9276 (2012-06-27)
The interaction between phenol molecules, both in their undissociated and dissociated states, and cationic dioctadecyl dimethylammonium chloride (DODAC) vesicles were thoroughly investigated using NMR techniques. In particular, diffusion and relaxation measurements, combined with the two sites Kärger model, were used
Colloids and surfaces. B, Biointerfaces, 97, 248-253 (2012-05-23)
In order to confirm that the cholesterol end groups of cholesterol-end capped polyethylene glycol really insert into the liposome bilayer and investigate how the incorporation affects the microenvironment of liposome bilayer, two kinds of molecular probes, namely Nile Red and
Journal of controlled release : official journal of the Controlled Release Society, 158(1), 72-77 (2011-10-29)
The adjuvant efficacy of cationic liposomes composed of dimethyldioctadecylammonium bromide and trehalose dibehenate (DDA:TDB) is well established. Whilst the mechanism behind its immunostimulatory action is not fully understood, the ability of the formulation to promote a 'depot effect' is a
Journal of controlled release : official journal of the Controlled Release Society, 160(2), 367-373 (2011-11-01)
The cationic lipid dioctadecyldimethylammonium bromide (DODAB) and the CpG oligonucleotide (CpG) have been separately used as potent immunoadjuvants driving Th1 responses. Here DODAB bilayer fragments (BF) and CpG (5'-TTGACGTTCG-3') assemblies have their physical properties and immunoadjuvant activity determined using ovalbumin
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