396R-1

Parvalbumin (EP300) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP300, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (396R-14); vial of 0.1 mL concentrate Research Use Only (396R-14-RUO); vial of 0.5 mL concentrate (396R-15); vial of 1.0 mL concentrate (396R-16); vial of 1.0 mL concentrate Research Use Only (396R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (396R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (396R-17); vial of 7.0 mL pre-dilute ready-to-use (396R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (396R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• isotype: IgG
• control: chromophobe renal cell carcinoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic
• Gene Information: human ... PVALB(5816)

Description

General description

Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis.^1-2 Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.^1-2 In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells).^1-3 Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC.^1-4 This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses.^1-4

Quality

IVD

IVD

IVD

RUO

Linkage

Parvalbumin Positive Control Slides, Product No. 396S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable