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Key Documents

357R-1

Sigma-Aldrich

TCL1 (EP105) Rabbit Monoclonal Primary Antibody

Synonym(s):

T-cell leukemia/lymphoma protein 1

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP105, monoclonal

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate Research Use Only (357R-14-RUO)
vial of 0.1 mL concentrated (357R-14)
vial of 0.5 mL concentrated (357R-15)
vial of 1.0 mL concentrate Research Use Only (357R-16-RUO)
vial of 1.0 mL concentrated (357R-16)
vial of 1.0 mL pre-dilute Research Use Only (357R-17-RUO)
vial of 1.0 mL predilute ready-to-use (357R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (357R-18-RUO)
vial of 7.0 mL predilute ready-to-use (357R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200 (concentrated)

control

follicular lymphoma, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic (tonsil), nuclear (tonsil, follicular lymphoma)

Gene Information

human ... TCL1A(8115)

General description

T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene. TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma.[1][2][3] TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed.[4] TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation.[5][6] TCL1 is overexpressed in Burkitt lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, and follicular lymphoma.[7][8][2]

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

TCL1 Positive Control Slides, Product No. 357S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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I Nakayama et al.
Pathology international, 50(3), 191-199 (2000-05-03)
The TCL1 gene, localized near the break point of chromosome 14q32.1 often involved in T cell leukemias, is also expressed in normal precursor T and B cells, and B cell lymphoma cell lines. We investigated the expression of the TCL1
J Roos et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 69(2), 59-66 (2001-12-26)
TCL1, MTCP1 and TCL1b are three members of a new family of oncogenes that are expressed in T cell leukemias of ataxia telangiectasia patients (T-PLL, T-CLL). TCL1 is located at 14q32.1 and activated by juxtaposition to the alpha/delta-locus at 14q11
Y Pekarsky et al.
Oncogene, 20(40), 5638-5643 (2001-10-19)
The TCL1 locus on human chromosome 14q32.1 is activated in T-cell leukemias by translocations and inversions that juxtapose it to regulatory elements of T-cell receptor genes. We isolated and characterized four genes at this locus, TCL1 and TCL1b (T-cell leukemia/lymphoma
J Takizawa et al.
Japanese journal of cancer research : Gann, 89(7), 712-718 (1998-09-17)
The TCL1 gene was recently cloned as a candidate target within the 14q32.1 breakpoint cluster region observed in T-cell malignancies. We examined the TCL1 gene expression in 21 patients with adult T-cell leukemia (ATL) and 5 cell lines, because ATL
Roberta Bichi et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(10), 6955-6960 (2002-05-16)
The TCL1 gene at 14q32.1 is involved in chromosomal translocations and inversions in mature T cell leukemias. These leukemias are classified either as T prolymphocytic leukemias, which occur very late in life, or as T chronic lymphocytic leukemias, which often
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