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347R-1

Sigma-Aldrich

Vimentin (SP20) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

SP20, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (347R-14)
vial of 0.5 mL concentrate (347R-15)
bottle of 1.0 mL predilute (347R-17)
vial of 1.0 mL concentrate (347R-16)
bottle of 7.0 mL predilute (347R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... VIM(7431)

General description

Anti-vimentin recognizes a 57kDa intermediate filament initially isolated from mouse fibroblast culture. Anti-vimentin is of limited value as a diagnostic tool in the setting of tumor pathology; however, it does serve as a useful control marker to ensure that the tissue has been properly preserved and processed.[1] Expression of vimentin, when used in conjunction with keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and schwannomas react strongly with vimentin. It labels a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. In the area of gynecologic tumors, endometrial endometrioid adenocarcinomas display a highly characteristic immunophenotype, with coexpression of low molecular wt. cytokeratin and vimentin.[1][2][3][4]

Linkage

Vimentin Positive Control Slides, Product No. 347S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000117490
0000117491
0000117506
0000096217
0000081988

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Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2006)
D J Dabbs et al.
Human pathology, 27(2), 172-177 (1996-02-01)
Carcinomas of endometrioid histology frequently arise in the endometrium, ovary, and endocervix and involve the pelvic tissues in women. Adenocarcinomas of psuedoendometrioid morphology developing in the colon also frequently involve the ovary. The authors retrospectively examined 97 adenocarcinomas from the
D J Dabbs et al.
The American journal of surgical pathology, 10(8), 568-576 (1986-08-01)
We examined the distribution of high- and low-molecular-weight cytokeratins, vimentin, and carcinoembryonic antigen (CEA) in normal endometrial glands and endocervical glands (20 cases each) and in endometrial and endocervical adenocarcinomas (29 cases and 15 cases respectively). Low- and high-molecular-weight cytokeratin
H Yaziji et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 20(1), 64-78 (2001-02-24)
Ancillary techniques such as immunohistochemistry (IHC) enable the surgical pathologist to extract additional information from fixed, deparaffinized tissue specimens and to provide data critical to optimal clinical management of the patient. In this review of applications of IHC to the

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