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30916

Sigma-Aldrich

pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin trifluoroacetate salt

≥96% (HPLC)

Synonym(s):

L-Pyroglutamyl-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin trifluoroacetate salt, Pyr-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C37H57N13O9 · xC2HF3O2
Molecular Weight:
827.93 (free base basis)
MDL number:
MFCD17215945
UNSPSC Code:
12352202
PubChem Substance ID:
329753603

assay

≥96% (HPLC)

form

powder

Storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C37H57N13O9.C2HF3O2/c1-19-17-29(53)59-27-18-21(10-11-22(19)27)45-31(54)24(8-5-15-43-36(39)40)47-32(55)23(7-3-4-14-38)49-35(58)30(20(2)51)50-34(57)25(9-6-16-44-37(41)42)48-33(56)26-12-13-28(52)46-26;3-2(4,5)1(6)7/h10-11,17-18,20,23-26,30,51H,3-9,12-16,38H2,1-2H3,(H,45,54)(H,46,52)(H,47,55)(H,48,56)(H,49,58)(H,50,57)(H4,39,40,43)(H4,41,42,44);(H,6,7)/t20-,23+,24+,25+,26+,30+;/m1./s1

Inchi Key

BHPUHMHLXQHSPN-HUQKKSBQSA-N

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Application

pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin was used as a substrate for the proprotein convertase PC1/3 and activity was measured by the fluorescence generated by the release of amino-4-methylcoumarin. [1]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBJ9540V
BCBS5839V
BCBR4558V
BCBC1874V
BCBC1874

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A Boudreault et al.
The Journal of biological chemistry, 273(47), 31574-31580 (1998-11-13)
The proprotein convertase PC1/3 belongs to the subtilisin/kexin-like endoprotease family and is synthesized as a preproenzyme. To investigate the function of its propeptide, murine proPC1/3 and preproPC1/3 were isolated from the inclusion bodies of recombinant preproPC1/3 baculovirus-infected insect cells, rendered
K Hatsuzawa et al.
The Journal of biological chemistry, 267(23), 16094-16099 (1992-08-15)
Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif. We have recently shown that a furin mutant lacking the
S S Molloy et al.
The Journal of biological chemistry, 267(23), 16396-16402 (1992-08-15)
Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells. Anion-exchange chromatography of culture supernatant from cells expressing a soluble truncated form

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