304R-1

Nerve Growth Factor Receptor (NGFR) (EP31) Rabbit Monoclonal Primary Antibody

• Synonym(s): CD271, Gp80-LNGFR, NGF receptor, TNFR superfamily, member 16, TNFRSF16, low affinity nerve growth factor receptor, low affinity neurotrophin receptor p75NTR, low-affinity nerve growth factor receptor, p75 ICD, p75(NTR), p75NR
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP31, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (304R-14); vial of 0.1 mL concentrate Research Use Only (304R-14-RUO); vial of 0.5 mL concentrate (304R-15); vial of 1.0 mL concentrate (304R-16); vial of 1.0 mL concentrate Research Use Only (304R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (304R-17-RUO); vial of 1.0 mL predilute ready-to-use (304R-17); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (304R-18-RUO); vial of 7.0 mL predilute ready-to-use (304R-18)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
• isotype: IgG
• control: breast
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic
• Gene Information: human ... NGFR(4804)

Description

General description

Nerve Growth Factor Receptor (NGFR), a 75 kd glycoprotein (also known as P-75NTR), is the first of the neurotrophin receptors to be isolated and is a member of the tumor necrosis factor (TNF) receptor family. NGFR is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, and neurotized nevi (type C melanocytes). Anti-NGFR has been shown to be a reliable marker for desmoplastic and neurotropic melanoma. Expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts, and thus, is an aid in identifying invasive lesions in the breast.[1]^,[2]^,[3]^,[4]^,[5]^,[6]

Quality

IVD

IVD

IVD

RUO

Linkage

Nerve Growth Factor Receptor (NGFR) Positive Control Slides, Product No. 304S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable