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222A-1

Sigma-Aldrich

A-1-Antichymotrypsin Rabbit Polyclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (222A-14)
vial of 0.5 mL concentrate (222A-15)
bottle of 1.0 mL predilute (222A-17)
vial of 1.0 mL concentrate (222A-16)
bottle of 7.0 mL predilute (222A-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

General description

Alpha-1-Antichymotrypsin Primary Antibody reacts with histiocytes and histiocytic neoplasms. Its major application is defining the presence of Alpha-1-Antichymotrypsin in histiocytes and tumors derived from them. In eosinophilic granuloma and malignant histiocytosis, the reaction for this marker is heterogeneous in intensity and distribution. In fibrous histiocytomas on the other hand, a diffuse homogeneous reaction may be observed. Acinar tumors of the pancreas and salivary gland may also exhibit Alpha-1-Antichymotrypsin positivity.

Quality


IVD
IVD
IVD
RUO

Linkage

A-1-Antichymotrypsin Positive Control Slides , Product No. 222S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000126148
0000126147
0000109798
0000107099
0000107100

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A Fabre et al.
Virchows Archiv : an international journal of pathology, 438(3), 312-315 (2001-04-24)
We describe a purely intraductal acinar cell carcinoma involving branch ducts of the pancreas in a 74-year-old man, which presented as recurrent episodes of acute pancreatitis. Endoscopic ultrasound examination revealed an intraductal mass bulging into the main pancreatic duct suggesting
Expression of protein markers in malignant hepatoma: evidence for genetic and epigenetic mechanisms.
P E Palmer et al.
Cancer, 45(6), 1424-1431 (1980-03-15)
L G Kindblom et al.
Human pathology, 13(9), 834-840 (1982-09-01)
The aim of this study was to localize alpha 1-antitrypsin, ferritin, and lysozyme by means of the indirect immunoperoxidase technique and to evaluate the significance of these antigens as markers of histiocytic differentiation in tumors of a supposed dual fibroblastic-histiocytic
Alpha 1-antitrypsin in human macrophages.
P Isaacson et al.
Lancet (London, England), 2(8149), 964-965 (1979-11-03)
I Reintoft et al.
Human pathology, 10(4), 419-424 (1979-07-01)
In 10 of 56 patients with primary liver carcinoma the nontumorous hepatocytes contained diastase resistant, periodic acid-Schiff positive and alpha-1-antitrypsin positive (immunoperoxidase technique) globules. This is a frequency of 18 per cent among patients with liver carcinoma against 6 per
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