174R-1

CD74 (EP167) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP167, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (174R-14); vial of 0.1 mL concentrate Research Use Only (174R-14-RUO); vial of 0.5 mL concentrate (174R-15); vial of 1.0 mL concentrate (174R-16); vial of 1.0 mL concentrate Research Use Only (174R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (174R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (174R-17); vial of 7.0 mL pre-dilute ready-to-use (174R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (174R-18-RUO)
• manufacturer/tradename: Cell Marque^®
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)
• isotype: IgG
• control: lymph node, tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic, membranous
• Gene Information: human ... CD74(972)

Description

General description

The CD74 antigen represents a membrane-bound subunit of the MHC Class II-associated invariant chain that is encoded by the gene located on Chromosome 5. The antibody recognizes nuclear and cytoplasmic antigens of MW 35 kD and 31 kD respectively. Anti-CD74 stains predominantly germinal center lymphocytes and those in the mantle cell region of the lymph node. It stains the cell membrane but a paranuclear globular labeling is also noted. Plasma cells are not labeled. Thymocytes are negative but dendritic cells are often labeled by anti-CD74. Anti-CD74 labels about 90% of low grade B-cell lymphomas and 20% of low grade T-cell lymphomas. In high-grade lymphomas the discriminatory power (B-cell vs. T-cell) is diminished. Reed-Sternberg cells are also labeled in approximately 60% of cases.¹

Quality

IVD

IVD

IVD

RUO

Linkage

CD74 Positive Control Slides, Product No. 174S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable