Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

View All Documentation

360457

Sigma-Aldrich

Acetonitrile

≥99.5%, ACS reagent

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

Sign Into View Organizational & Contract Pricing

Select a Size

500 ML
$93.80
1 L
$148.00
2.5 L
$304.00
18 L
$1,460.00
4 X 4 L
$1,750.00
200 L
$9,153.00

$93.80

List Price$134.00Save 30%
Web-Only Promotion

Available to ship onMay 01, 2025Details

Request a Bulk Order
All Photos(3)

Select a Size

Change View
500 ML
$93.80
1 L
$148.00
2.5 L
$304.00
18 L
$1,460.00
4 X 4 L
$1,750.00
200 L
$9,153.00

About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
Beilstein/REAXYS Number:
741857
EC Number:
200-835-2
MDL number:
MFCD00001878
UNSPSC Code:
12191502
eCl@ss:
39031501
PubChem Substance ID:
329755257
NACRES:
NA.21
grade:
ACS reagent
assay:
≥99.5%
bp:
81-82 °C (lit.)
vapor pressure:
72.8 mmHg ( 20 °C)

$93.80

List Price$134.00Save 30%
Web-Only Promotion

Available to ship onMay 01, 2025Details

Request a Bulk Order

Product Name

Acetonitrile, ACS reagent, ≥99.5%

grade

ACS reagent

Quality Level

200

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.5%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

dilution

(for analytical testing)

impurities

≤0.3% water
≤0.6 μeq/g Titr. base
≤8 μeq/g Titr. acid

evapn. residue

≤0.005%

color

APHA: ≤10

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

format

neat

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Acetonitrile (MeCN, ACN) is an aliphatic nitrile that is commonly used as a reaction solvent as well as a chemical intermediate in organic synthesis. In many chromatographic techniques, MeCN is used as a mobile phase solvent due to its low viscosity, high elution strength, and miscibility in water.

Application

Acetonitrile can be used as a solvent in:      
  • The solid-phase peptide synthesis.     
  • The sialylation reactions.      
  • The synthesis of copper nanoparticles by reduction of copper nitrate salt using NaBH4. During the preparation, ACN acts as a protecting solvent, which prevents the oxidation of nanoparticles.      
  • The preparation of diaryl selenides by Cu-catalyzed coupling reaction between aryl iodides and diphenyl diselenide. In this process, ACN also functions as a ligand for the copper catalyst to increase its catalytic activity.

Features and Benefits

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS) ,with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SHBS6784
SHBS5729
SDBB2854
MKCW6175
SHBS5077

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 4

1 of 4

Acetonitrile EMPLURA®, for preparative purposes

Supelco

1.15500

Acetonitrile

Acetonitrile analytical standard

Supelco

45983

Acetonitrile

Acetonitrile

Sigma-Aldrich

L010080

Acetonitrile

Acetonitrile for preparative chromatography Prepsolv™

Supelco

1.13358

Acetonitrile

Purification of acetonitrile.
Walter M and Ramaley L.
Analytical Chemistry, 45(1), 165-166 (1973)
Timo Glatter et al.
Molecular systems biology, 5, 237-237 (2009-01-22)
Protein complexes represent major functional units for the execution of biological processes. Systematic affinity purification coupled with mass spectrometry (AP-MS) yielded a wealth of information on the compendium of protein complexes expressed in Saccharomyces cerevisiae. However, global AP-MS analysis of
Elke H J Krekels et al.
Clinical pharmacokinetics, 53(6), 553-563 (2014-02-06)
From a previously validated paediatric population pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 μg/kg(1.5)/h, with a 50 % dose reduction in neonates with a postnatal age (PNA) <10 days, yield similar morphine and metabolite concentrations
Hélène Hall et al.
Brain : a journal of neurology, 137(Pt 9), 2493-2508 (2014-07-27)
The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is
View All Related Papers

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is the mouth of the bottle sealed?

    1 answer

    1. This product is not packaged in Sure/Seal bottles. The 100mL, 1L, 2.5L, and 4L options are packaged in amber glass bottles with polypropylene screw caps with HPDE/PTFE liners. The 18 L size is packaged in carbon steel drums. Please see the link below to review an anydrous Acetonitrile product packaged in Sure/Seal bottles:
      https://www.sigmaaldrich.com/product/sial/271004

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service