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I4386

Iodoacetic acid

≥98.0% (T)

Synonym(s):

2-Iodoacetic acid

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10 g

Available to ship TODAYfromMILWAUKEE

$65.20
25 g

Available to ship TODAYfromMILWAUKEE

$122.00
100 g

Available to ship TODAYfromMILWAUKEE

$367.00

About This Item

Linear Formula:
ICH2CO2H
CAS Number:
Molecular Weight:
185.95
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-590-1
Beilstein/REAXYS Number:
1739079
MDL number:

$65.20


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biological source

synthetic

Quality Segment

assay

≥98.0% (T)

form

powder or flakes

color

white to yellow

mp

77-79 °C (lit.)

solubility

H2O: soluble, clear to hazy

storage temp.

−20°C

SMILES string

OC(=O)CI

InChI

1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)

InChI key

JDNTWHVOXJZDSN-UHFFFAOYSA-N

Application

Reagent for the modification of cysteine residues in proteins.
Iodoacetic acid has been used as an alkylating agent for antibody AR37, serum proteins and strawberry proteome samples extracted from different stages of ripened fruit.

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

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This Item
I2512I914857858
biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

assay

≥98.0% (T)

assay

≥98%

assay

≥98%

assay

≥99.5% (NT)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

powder or flakes

form

powder

form

powder

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: soluble, clear to hazy

solubility

H2O: 100 mg/mL

solubility

H2O: 0.5 M, clear, colorless

solubility

methanol: 0.1 M at 20 °C, clear, colorless


pictograms

Skull and crossbonesCorrosion

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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Global Trade Item Number

SKUGTIN
I4386-10G04061833856789
I4386-25G04061833856796
I4386-100G04061833856772

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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