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T1410900

Tiaprofenic acid

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-Tiaprofenic acid

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50 MG
$153.00

About This Item

Empirical Formula (Hill Notation):
C14H12O3S
CAS Number:
33005-95-7
Molecular Weight:
260.31
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

tiaprofenic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[s]1c(ccc1C(=O)c2ccccc2)C(C)C(=O)O

InChI

1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)

InChI key

GUHPRPJDBZHYCJ-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

application

Tiaprofenic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H361

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A Lahoz et al.
Chemical research in toxicology, 14(11), 1486-1491 (2001-11-20)
Drug-induced photoallergy is an immune adverse reaction to the combined effect of drugs and light. From the mechanistic point of view, it first involves covalent binding of drug to protein resulting in the formation of a photoantigen. Hence, determination of
C Agapakis-Caussé et al.
Photochemistry and photobiology, 71(5), 499-505 (2000-05-20)
In order to determine whether or not tiaprofenic acid (TPA) could cause cellular DNA damage, human fibroblasts were irradiated in the presence of the drug and subsequently examined by means of the comet assay. This led to the observation that
Jana G Hashash et al.
Clinical therapeutics, 29(11), 2448-2452 (2007-12-26)
A 40-year-old previously healthy white man presented to the emergency department at American University of Beirut Medical Center, Beirut, Lebanon, with severe upper abdominal pain of 36-hour duration. The pain started a few hours after the intake of a single
Z Sarabia et al.
Journal of photochemistry and photobiology. B, Biology, 58(1), 32-36 (2001-02-24)
The skin is repeatedly exposed to solar ultraviolet radiation. Photoreaction of drugs in the body may result in phototoxic or photoallergic side effects. Non-steroidal anti-inflammatory drugs, such as tiaprofenic acid (TPA) and the closely related isomer suprofen (SUP) are frequently
D L Scott et al.
Rheumatology (Oxford, England), 39(10), 1095-1101 (2000-10-18)
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat osteoarthritis (OA), though their long-term efficacy is uncertain. We report a comparison of the symptomatic responses to therapy with tiaprofenic acid, indomethacin and placebo over 5 yr. A parallel-group, randomized, single-blind
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