PHR1955

Mepivacaine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Mepivacaine hydrochloride, 1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
• Empirical Formula (Hill Notation): C₁₅H₂₂N₂O · HCl
• CAS Number: 1722-62-9
• Molecular Weight: 282.81
• EC Number: 217-023-9
• MDL number: MFCD00144738
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 699; traceable to Ph. Eur. M0370000; traceable to USP 1387002
• API family: mepivacaine
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl
• InChI: 1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
• InChI key: RETIMRUQNCDCQB-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Application

Mepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na⁺ inward current, as well as the steady-state K⁺ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB1955 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H336
• pcodes: P261 - P264 - P270 - P271 - P301 + P310 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable