PHR1677

Anthralin (Dithranol)

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Dithranol, 1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin
• Empirical Formula (Hill Notation): C₁₄H₁₀O₃
• CAS Number: 1143-38-0
• Molecular Weight: 226.23
• Beilstein/REAXYS Number: 2054360
• EC Number: 214-538-0
• MDL number: MFCD00053409
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823549
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to Ph. Eur. D2953000; traceable to USP 1039006
• API family: anthralin, dithranol
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 178-181 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: Oc1cccc2Cc3cccc(O)c3C(=O)c12
• InChI: 1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2
• InChI key: NUZWLKWWNNJHPT-UHFFFAOYSA-N

Description

General description

Anthralin (Dithranol) is the synthetic form of chrysarobin. It is widely used as a medication for the human skin affected with psoriasis and in short contact therapy to minimize the staining, irritation, etc.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Anthralin (Dithranol) may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high pressure liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6122 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable