PHR1258

Chloroquine phosphate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Chloroquine diphosphate salt, N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-dimethyl-1,4-pentanediamine diphosphate salt
• Empirical Formula (Hill Notation): C₁₈H₂₆ClN₃ · 2H₃PO₄
• CAS Number: 50-63-5
• Molecular Weight: 515.86
• Beilstein/REAXYS Number: 4223142
• EC Number: 200-055-2
• MDL number: MFCD00069852
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823259
• NACRES: NA.24

Properties

• biological source: synthetic
• Quality Level: 300
• grade: certified reference material; pharmaceutical secondary standard
• agency: BP; EP; USP; traceable to USP 1118000
• vapor pressure: <0.0000001 kPa ( 25 °C)
• API family: chloroquine
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• storage condition: protect from light
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• color: white to yellow
• pH: 3.5-4.5 (10% in aqueous solution, pH <6.0)
• mp: 200 °C (dec.) (lit.)
• solubility: water: 50 g/L; benzene: practically insoluble; chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
• InChI key: QKICWELGRMTQCR-UHFFFAOYSA-N

Description

General description

Chloroquine phosphate is a phosphate salt of chloroquine. It belongs to the class of aminoquinoline drugs utilized as antimalarials and amebicides.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chloroquine phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin-layer chromatography (TLC) and liquid chromatography (LC).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3715 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable