NIST921

Cortisol (Hydrocortisone)

NIST^® SRM^® 921

• Synonym(s): Hydrocortisone, 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Empirical Formula (Hill Notation): C₂₁H₃₀O₅
• CAS Number: 50-23-7
• Molecular Weight: 362.46
• Beilstein/REAXYS Number: 1354819
• MDL number: MFCD00011654
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• Quality Level: 100
• form: solid
• packaging: pkg of 1 g
• mp: 211-214 °C (lit.)
• application(s): pharmaceutical
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

Description

General description

This Standard Reference Material is certified as a chemical of known purity. It is intended primarily for use in the calibration and standardization of procedures for cortisol determinations and for routine critical evaluation of the daily working standards used in these procedures. For more information, please refer to the SDS and COA.

SRM 921_cert

SRM 921_SDS

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Legal Information

NIST is a registered trademark of National Institute of Standards and Technology

SRM is a registered trademark of National Institute of Standards and Technology

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360Df,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable