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Key Documents

M5279

Supelco

Mebhydroline 1,5-naphthalenedisulfonate salt

analytical standard

Synonym(s):

9-Benzyl-N-methyl-1,2,3,4-tetrahydro-α-carboline

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About This Item

Linear Formula:
C19H20N2 · 1/2C10H8O6S2
CAS Number:
Molecular Weight:
420.52
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.CN3CCc4c(C3)c5ccccc5n4Cc6ccccc6.CN7CCc8c(C7)c9ccccc9n8Cc%10ccccc%10

InChI

1S/2C19H20N2.C10H8O6S2/c2*1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16/h2*2-10H,11-14H2,1H3;1-6H,(H,11,12,13)(H,14,15,16)

InChI key

CJUOSBUQOWKEKJ-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

H1 Histamine receptor antagonist

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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J McEwen et al.
The Medical journal of Australia, 2(11), 523-525 (1982-11-27)
Mebhydrolin napadisylate is an antihistamine marketed in Australia as Fabahistin, and as an ingredient of Fabahistin Plus. Since June, 1973, 11 Australian reports associating this drug with either agranulocytosis or neutropenia have been received by the Adverse Drug Reactions Advisory
L E Kucheriavykh et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 86(12), 1669-1675 (2001-02-24)
Administration of the acetylcholine esterase antagonist aminostigmin increased the number of neutrophils in the estrus phase and the number of lymphocytes in the diestrus phase in rats. Histamine decreased both the neutrophils and lymphocytes at all stages of the estrus
J Waitzinger et al.
International journal of clinical pharmacology and therapeutics, 33(7), 373-383 (1995-07-01)
The efficacy of a multiple oral dose treatment with mebhydroline (Omeril coated tablets, 100 mg t.i.d.) was examined in 3 studies which were performed in a randomized, double-blind and placebo-controlled 2-way cross-over design. A second target was to investigate the
M M Desnitskaia et al.
Farmakologiia i toksikologiia, 43(1), 62-65 (1980-01-01)
The effect of antihistaminic drugs, histamine and their combinations on the development of anaphylactic shock and the period of repeated resolution doses was studied in rabbit experiments. It was established that administration of dimedrol during sensibilization aggravated while diazolin and
Chi-Ling Chen et al.
Gastroenterology, 135(1), 111-121 (2008-05-29)
This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C virus (HCV) serostatus, and explored the possible joint influence of obesity/diabetes and HBV/HCV infections

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