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M3157

Supelco

Minaprine dihydrochloride

analytical standard

Synonym(s):

N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

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About This Item

Empirical Formula (Hill Notation):
C17H22N4O · 2HCl
CAS Number:
25905-77-5
Molecular Weight:
371.30
EC Number:
247-329-8
MDL number:
MFCD00083410
UNSPSC Code:
41116107
PubChem Substance ID:
329817964
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3

InChI

1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

InChI key

GNUCGROXDZMCJI-UHFFFAOYSA-N

Gene Information

human ... ACHE(43) , CHRM1(1128) , DRD2(1813) , HTR2B(3357) , HTR2C(3358) , MAOA(4128) , SLC6A4(6532)
rat ... Ache(83817) , Camk2a(25400) , Prkca(24680)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antidepressant

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
080H0353

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D Wheatley
The British journal of psychiatry : the journal of mental science, 161, 113-115 (1992-07-01)
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with
[Three cases of acute agranulocytosis: caused by minaprine?].
Y Bastion et al.
Presse medicale (Paris, France : 1983), 22(2), 82-83 (1993-01-23)
S Chaki et al.
Neurochemistry international, 24(1), 37-41 (1994-01-01)
Involvement of protein kinase C (PKC) activation in the regulation of acetylcholine (ACh) release from rat hippocampal slices by minaprine, [3(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine] was investigated. Phorbol esters such as 4 beta-phorbol 12,13-dibutylate (PDBu) and 12-o-tetradecanoylphorbol 13-acetate (TPA) enhanced high K(+)-evoked [3H]ACh release
Antidepressant response follows an exponential decay curve: replication and extension.
W Boyer
Journal of clinical psychopharmacology, 17(5), 426-427 (1997-10-08)
A Imperato et al.
Neuroscience letters, 166(1), 69-72 (1994-01-17)
Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced
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