H8760

Hydroflumethiazide

analytical standard, ~97%

• Synonym(s): 3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₈H₈F₃N₃O₄S₂
• CAS Number: 135-09-1
• Molecular Weight: 331.29
• EC Number: 205-173-8
• MDL number: MFCD00057316
• UNSPSC Code: 41116107
• PubChem Substance ID: 329815253

Properties

• grade: analytical standard
• assay: ~97%
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• SMILES string: O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O
• InChI: 1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
• InChI key: DMDGGSIALPNSEE-UHFFFAOYSA-N
• Gene Information: human ... SLC12A3(6559)

Description

General description

Hydroflumethiazide is a thiazide diuretic drug, which acts like a potent antihypertensive agent.[1] It is used in combination with spironolactone to minimize the excessive loss of potassium in hypokalemic patients who require diuretic therapy.[2]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).[3]

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P280 - P342 + P311
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves