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H5395

Supelco

Hydrocortisone 17-valerate

analytical standard

Synonym(s):

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate, Cortisol 17-valerate

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About This Item

Empirical Formula (Hill Notation):
C26H38O6
CAS Number:
57524-89-7
Molecular Weight:
446.58
EC Number:
260-786-8
MDL number:
MFCD00083365
UNSPSC Code:
41116107
PubChem Substance ID:
329815218
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCC)C(=O)CO

InChI

1S/C26H38O6/c1-4-5-6-22(31)32-26(21(30)15-27)12-10-19-18-8-7-16-13-17(28)9-11-24(16,2)23(18)20(29)14-25(19,26)3/h13,18-20,23,27,29H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1

InChI key

FZCHYNWYXKICIO-FZNHGJLXSA-N

Gene Information

human ... NR3C1(2908)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

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Erythematous patches and plaques on the chest with induration of the breasts. Metastatic papillary RCC in dermal lymphatics.
Yevgeniy Balagula et al.
Archives of dermatology, 147(10), 1215-1220 (2011-10-19)
K M Tramposch
Inflammation, 17(5), 531-536 (1993-10-01)
Synthetic glucocorticosteroids are widely used in clinical dermatology in the treatment of a number of inflammatory skin disorders. However, cutaneous side effects such as induction of skin atrophy are among the factors that limit the chronic use of this class
'Eye-catching' dermatitis for the skin surgeon.
R K Roenigk
Ophthalmic plastic and reconstructive surgery, 15(3), 149-150 (1999-06-04)
J Sefton et al.
Cutis, 32(1), 89-91 (1983-07-01)
Evaluations of the comparative efficacy and safety of a newly developed emollient ointment formulation of hydrocortisone valerate 0.2 percent were made in two double-blind, multicenter trials involving 145 patients with atopic dermatitis. Data are presented which indicate that hydrocortisone valerate
J G Alford et al.
Agents and actions, 37(3-4), 260-267 (1992-11-01)
We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by edema, cell infiltration and epidermal hyperplasia. In order to characterize the cell infiltrate during the establishment
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