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F8755

Supelco

Fenbufen

analytical standard

Synonym(s):

γ-Oxo-(1,1′-biphenyl)-4-butanoic acid

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About This Item

Linear Formula:
C6H5C6H4CO(CH2)2CO2H
CAS Number:
36330-85-5
Molecular Weight:
254.28
EC Number:
252-979-0
MDL number:
MFCD00056701
UNSPSC Code:
41116107
PubChem Substance ID:
329799772
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

184-187 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2

InChI

1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)

InChI key

ZPAKPRAICRBAOD-UHFFFAOYSA-N

Gene Information

human ... MMP2(4313) , MMP3(4314) , MMP9(4318)

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General description

Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications.[1] Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.[2]

Application

Fenbufen may be used as an analytical reference standard for the quantification of the analyte in biological samples[1][2] and pharmaceutical formulations[2] using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

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Kun-I Lin et al.
Molecules (Basel, Switzerland), 15(12), 8796-8803 (2010-12-04)
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10
Arkadiusz Pomykalski et al.
Acta poloniae pharmaceutica, 62(3), 171-176 (2005-10-01)
A methods for the determination of fenbufen and ketoprofen in pharmaceuticals by classical spectrophotometry--zero order derivative, first and second order derivatives spectrophotometry is described. using "peak-peak" (P-P) and, "peak-zero" (P-O) measurements. The calibration curves are linear within the concentration range
Zehadin Gashi et al.
Journal of pharmaceutical sciences, 98(11), 4216-4228 (2009-08-01)
The present work aims at the application of several methods to explain differences in the physical interaction of some aryl propionic acid derivatives (ibuprofen [IBP], ketoprofen [KET], flurbiprofen [FLU], naproxen [NAP], fenbufen [FEN]) with poly(vinylpyrrolidone) (PVP) K30, stored together at
T Masukawa et al.
Japanese journal of pharmacology, 76(4), 425-429 (1998-06-12)
Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by
Huarong Zhang et al.
European journal of mass spectrometry (Chichester, England), 12(5), 291-299 (2007-04-04)
The inclusion complexes of four ligands binding to cyclodextrins (CDs) were studied by electrospray ionization mass spectrometry (ESI-MS) and the dissociation constants of the complexes were obtained. The 1:1 stoichiometric inclusion complex was found in the system of CD and
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