This product may be reconstituted in DMSO at 8 mg/mL.
E3764
Enoxacin
analytical standard
Synonym(s):
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
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All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C15H17FN4O3
CAS Number:
Molecular Weight:
320.32
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
Recommended Products
grade
analytical standard
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cc(F)c(nc12)N3CCNCC3
InChI
1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)
InChI key
IDYZIJYBMGIQMJ-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544)
General description
Chemical structure: fluoroquinolone
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Hydrophilic fluorquinolone antibiotic. Substrate of NorA, an energy dependent drug efflux pump in Staphylococcus aureus. Expression of NorA is responsible for some drug resistant infections.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Fuxing Liu et al.
Frontiers in bioengineering and biotechnology, 8, 131-131 (2020-04-08)
Recently, many studies have demonstrated that microRNAs (miRNAs) are new small molecule drug targets. Identifying small molecule-miRNA associations (SMiRs) plays an important role in finding new clues for various human disease therapy. Wet experiments can discover credible SMiR associations; however
Julien Poissy et al.
Antimicrobial agents and chemotherapy, 54(11), 4765-4771 (2010-09-02)
The prevalence of extensively drug-resistant tuberculosis (XDR-TB), defined as TB that is resistant to isoniazid, rifampin, fluoroquinolones, and aminoglycosides, is rising worldwide. The extent of Mycobacterium tuberculosis resistance to fluoroquinolones depends on the mutation in the DNA gyrase, the only
Sonia Melo et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(11), 4394-4399 (2011-03-04)
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways. The disruption of miRNAs and their processing machineries also contributes to the development of human tumors. A common scenario
Douglas D Young et al.
Journal of the American Chemical Society, 132(23), 7976-7981 (2010-06-10)
MicroRNAs are a recently discovered new class of important endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new
Julia Breger et al.
PLoS pathogens, 3(2), e18-e18 (2007-02-06)
There is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show that Candida albicans, as
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In what solvent can Product E3764, Enoxacin, be reconstituted?
1 answer-
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What class of antibiotics does Product E3764, Enoxacin, belong to?
1 answer-
Enoxacin is a broad spectrum fluoroquinolone antibiotic used in the treatment of urinary tract infections.
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What working concentration has been reported for Product E3764, Enoxacin?
1 answer-
Enoxacin has been used at 1 mM on cultured Calu-3 cells to inhibit transepithelial transport of ciprofloxacin, as reported in Antimicrob. Agents Chemother. 41(12), 2693-2698 (1997).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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