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D136808

Sigma-Aldrich

2,2-Dimethoxypropane

reagent grade, 98%

Synonym(s):

Acetone dimethyl acetal

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25 ML
$22.56
500 ML
$59.07
2.5 L
$208.80
18 L
$926.00

$22.56

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25 ML
$22.56
500 ML
$59.07
2.5 L
$208.80
18 L
$926.00

About This Item

Linear Formula:
(CH3)2C(OCH3)2
CAS Number:
77-76-9
Molecular Weight:
104.15
Beilstein/REAXYS Number:
635678
EC Number:
201-056-0
MDL number:
MFCD00008479
UNSPSC Code:
12352100
PubChem Substance ID:
24893272
NACRES:
NA.21
grade:
reagent grade
assay:
98%
bp:
83 °C (lit.)
vapor pressure:
60 mmHg ( 15.8 °C)

$22.56

List Price$28.30Save 20%
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

grade

reagent grade

Quality Level

200

vapor density

3.59 (vs air)

vapor pressure

60 mmHg ( 15.8 °C)

assay

98%

form

liquid

expl. lim.

31 %, 58 °F
6 %, 27 °F

dilution

(for analytical testing)

refractive index

n20/D 1.378 (lit.)

bp

83 °C (lit.)

density

0.847 g/mL at 25 °C (lit.)

functional group

ether
ketal

SMILES string

COC(C)(C)OC

InChI

1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3

InChI key

HEWZVZIVELJPQZ-UHFFFAOYSA-N

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General description

2,2-Dimethoxypropane (DMP) is an organic building block commonly employed as a precursor to generate 2-methoxypropene (MPP). The degradation study of DMP in ionic liquids showed the formation of MPP and 2-ethoxypropene (EPP) in an identical ratio due to the tunneling effect.[1] Conformational analysis of DMP based on ab initio calculations and matrix isolation infrared spectroscopy has been reported.[2] DMP reacts with water to produce methanol and acetone. This reaction has been employed in a method for the quantification of water in natural products by gas-liquid chromatography.[3] Acidified DMP has been employed for the dehydration of biological samples.[4]

Application

Reagent for the preparation of 1,2-diols as acetonides.[5]

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

14.0 °F - closed cup

flash_point_c

-10 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
STBL4092
MKCM9898
MKCV5619
STBK4276
STBL3322

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Greene, T.W. Wuts, P.G.M.
Protective Groups in Organic Synthesis, 123-123 (1991)
The importance of tunneling effect to the decomposition of 2, 2-dimethoxypropane and 2,2-diethoxypropane.
Jiang H, et al.
Chemical Physics Letters, 406(4), 489-494 (2005)
Gas chromatographic determination of water in natural products by reaction with 2,2-dimethoxypropane.
Mary NY.
Journal of Pharmaceutical Sciences, 58(9), 1089-1092 (1969)
Davit Jishkariani et al.
ACS nano, 11(8), 7958-7966 (2017-08-05)
Janus nanoparticles (NPs) often referred to as nanosized analogs of molecular surfactants are amphiphilic structures with potential applications in materials science, biomedicine, and catalysis, and their synthesis and self-assembly into complex architectures remain challenging. Here, we demonstrate the preparation of
K Conway et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 74(1), 20-26 (1999-04-06)
Chemical dehydration can be accomplished using 2,2-dimethoxypropane (DMP). In the presence of an acid catalyst, this liquid reacts with water generating methanol and acetone as products. Although DMP is more expensive per milliliter than ethanol and other solvents used for
View All Related Papers

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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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