Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

D0480000

Desacetylvinblastine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

O4-Deacetylvincaleukoblastine

Sign Into View Organizational & Contract Pricing

Select a Size

2 EA
$153.00

$153.00

Check Cart for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
2 EA
$153.00

About This Item

Empirical Formula (Hill Notation):
C44H56N4O8
CAS Number:
3352-69-0
Molecular Weight:
768.94
MDL number:
MFCD01675267
UNSPSC Code:
41116107
NACRES:
NA.24

$153.00

Check Cart for Availability
Request a Bulk Order

grade

pharmaceutical primary standard

API family

vinblastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

dry ice

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)O.N21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@H]5[C@@]([C@@H]([C@]6([C@@H]7N(CCC754)CC=C6)CC)O)(O)C(=O)OC)C)C(=O)OC

InChI

1S/C44H56N4O8.H2O4S/c1-7-40(52)22-26-23-43(38(50)55-5,34-28(14-18-47(24-26)25-40)27-12-9-10-13-31(27)45-34)30-20-29-32(21-33(30)54-4)46(3)36-42(29)16-19-48-17-11-15-41(8-2,35(42)48)37(49)44(36,53)39(51)56-6;1-5(2,3)4/h9-13,15,20-21,26,35-37,45,49,52-53H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t26-,35+,36-,37-,40+,41-,42?,43+,44+;/m1./s1

InChI key

VSMLZADJIZSDKN-MEFFJABKSA-N

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desacetylvinblastine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

O van Tellingen et al.
Journal of chromatography, 553(1-2), 47-53 (1991-08-16)
Procedures for the determination of vinblastine (VBL), 4-O-deacetylvinblastine (DVBL) and 4-O-deacetylvinblastine-3-oic acid (DVBLA) in biological samples using high-performance liquid chromatography (HPLC) combined with selective sample clean-up are presented. VBL and DVBL were determined in plasma and urine using ion-exchange normal-phase
J M Labus et al.
Cytometry, 13(3), 275-281 (1992-01-01)
Clinical investigations utilizing murine monoclonal antibodies require techniques for the detection of the human anti-mouse antibody (HAMA) response in patient serum. We report here a flow cytometric assay for the quantitation of HAMA. Commercially available beads conjugated with goat anti-mouse
M E Spearman et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 695-703 (1987-05-01)
The monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB (LY256787), and free 4-desacetylvinblastine (DAVLB) were administered i.v. to male athymic nude mice bearing P3/UCLA human lung adenocarcinoma tumors. Although the plasma pharmacokinetics were similar between LY256787 and DAVLB (terminal plasma half-lives of 62
A De Bruyn et al.
Planta medica, 55(4), 364-366 (1989-08-01)
A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.
O van Tellingen et al.
Cancer chemotherapy and pharmacology, 32(4), 286-292 (1993-01-01)
We have developed and validated a selective analytical procedure, based on ion-exchange normal-phase liquid chromatography with fluorescence detection and liquid-liquid extraction, for the analysis of vinblastine (VBL) in biological matrices. The assay is suitable for the determination of the parent

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service