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D007

Supelco

R(−)-Chloroethylnorapomorphine hydrochloride

analytical standard

Synonym(s):

NCA hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H18ClNO2 · HCl
CAS Number:
75344-87-5
Molecular Weight:
352.25
MDL number:
MFCD00069237
UNSPSC Code:
41116107
PubChem Substance ID:
329798579
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥85%

form

solid

storage condition

desiccated
protect from light

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

off-white

solubility

0.1 M HCl: soluble
H2O: soluble
aqueous base: unstable

format

neat

storage temp.

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CCCl)CCc4cccc(c34)-c2c1O

InChI

1S/C18H18ClNO2.ClH/c19-7-9-20-8-6-11-2-1-3-13-16(11)14(20)10-12-4-5-15(21)18(22)17(12)13;/h1-5,14,21-22H,6-10H2;1H/t14-;/m1./s1

InChI key

ASPGECRWCJCPPO-PFEQFJNWSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Irreversible dopamine receptor alkylating agent

Reconstitution

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. Solutions should be freshly prepared.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H336

Hazard Classifications

STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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G J Kilpatrick et al.
European journal of pharmacology, 107(1), 71-78 (1984-12-15)
N-(chloroethyl)-norapomorphine (NCA) irreversibly inhibits striatal dopamine function, the binding of dopamine agonist ligands and dopamine-stimulated adenylate cyclase. A selective interaction of [3H]NCA with dopamine receptor sites would be of use in the characterisation and isolation of brain dopamine receptors. In
J Lehmann et al.
European journal of pharmacology, 90(4), 393-400 (1983-06-17)
(-)-N-(2-Chloroethyl)-norapomorphine [-)-NCA) inhibited in a concentration-dependent manner the electrically evoked [3H]acetylcholine release in slices of cat caudate. The inhibition by (-)-NCA was reversible and antagonized by the benzamide neuroleptic S-sulpiride. Although (-)-NCA is an irreversible antagonist at some behaviorally relevant
S A Cohen et al.
Journal of medicinal chemistry, 26(10), 1348-1353 (1983-10-01)
The rates and mechanism of solvolysis of (-)-N-(2-chloroethyl)norapomorphine (NCA, 1c) in aqueous solution have been examined by reversed-phase liquid chromatography (HPLC) to follow the levels of starting material and products. The first-order rate constants for aziridinium ion formation at 25
The effects of (-)N-(chloroethyl)-norapomorphine on [3H]-apomorphine binding to striatal dopamine receptors.
M W Goosey et al.
Biochemical pharmacology, 31(22), 3693-3694 (1982-11-15)
Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: effects of (-)-N-(2-chloroethyl)-norapomorphine.
J Lehmann et al.
European journal of pharmacology, 77(1), 85-86 (1982-01-08)
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