C8731

Calcium pantothenate

meets USP testing specifications, monograph mol wt. 476.53 (C₁₈H₃₂CaN₂O₁₀)

• Synonym(s): D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B₅
• Linear Formula: HOCH₂C(CH₃)₂CH(OH)CONHCH₂CH₂CO₂ ·1/2Ca
• CAS Number: 137-08-6
• Molecular Weight: 238.27
• Beilstein/REAXYS Number: 3769272
• EC Number: 205-278-9
• MDL number: MFCD00002766
• UNSPSC Code: 12352205
• eCl@ss: 34058012
• PubChem Substance ID: 24893098
• NACRES: NA.21

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• agency: USP/NF; meets USP testing specifications
• form: crystalline; powder
• mol wt: monograph mol wt. 476.53 (C₁₈H₃₂CaN₂O₁₀)
• technique(s): cell culture | mammalian: suitable; cell culture | plant: suitable
• color: white
• application(s): pharmaceutical (small molecule)
• storage temp.: 2-8°C
• SMILES string: CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
• InChI: 1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1
• InChI key: FAPWYRCQGJNNSJ-UBKPKTQASA-L

Description

General description

Vitamin B5 or pantothenic acid is a viscous oil that is soluble in ethanol and water. It is produced by plants and microorganisms. d-(+)pantothenic acid is the naturally occurring form of pantothenic acid and is biologically active.

Application

Calcium pantothenate has been used:

• as a component of vitamin solution for synthetic media
• as a component of vitamin mix for the ICS medium mix
• as a component of a chemically defined diet for metal depletion studies in Drosophila
• as a supplement to study coenzyme A metabolism in mouse models of non-alcoholic steatohepatitis

Precursor in the biosynthesis of coenzyme A.

Biochem/physiol Actions

The calcium salts of panthenol are commonly used for pharmaceutical preparations. Pantothenate is a component of coenzyme A and is useful in its synthesis. Pantothenic acid is also involved in the synthesis of heme, cholesterol and fatty acids. Since vitamin B5 is found in all foods, its deficiency is not commonly observed.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)