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B0760

Supelco

Bufexamac

analytical standard

Synonym(s):

2-(p-Butoxyphenyl)acetohydroxamic acid

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About This Item

Empirical Formula (Hill Notation):
C12H17NO3
CAS Number:
2438-72-4
Molecular Weight:
223.27
EC Number:
219-451-1
MDL number:
MFCD00078936
UNSPSC Code:
41116107
PubChem Substance ID:
329773128
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CCCCOc1ccc(CC(=O)NO)cc1

InChI

1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

InChI key

MXJWRABVEGLYDG-UHFFFAOYSA-N

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General description

Bufexamac is a drug with antipyretic, analgesic and anti-inflammatory properties.[1][2]

Application

Bufexamac may be used as a reference standard in the determination of bufexamac in pharmaceutical formulations using high-performance liquid chromatography (HPLC).[3]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBW0026
011M1532V
011M1532

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Determination of bufexamac in cream and ointment by high-performance liquid chromatography.
Kamata K, et al.
Journal of Chromatography A, 370(3), 344-347 (1986)
A Schnuch et al.
Deutsche medizinische Wochenschrift (1946), 130(50), 2881-2886 (2005-12-13)
Bufexamac is a non-steroidal, anti-inflammatory drug used in the topical treatment of atopic dermatitis, stasis dermatitis and perianal eczema. The substance is known to cause severe allergic contact dermatitis (ACD) as an adverse effect (AE), which may be indistinguishable from
Miyuki Inaoka et al.
Experimental dermatology, 15(12), 981-990 (2006-11-07)
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to be risk factors for a systemic inflammatory syndrome in viral infections. Innate immune cells are likely to represent the preferential targets for the deleterious effects of NSAIDs in patients with viral infections. We
Katrin Kügler et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 3(12), 979-986 (2006-01-13)
Anogenital dermatoses (AGD) are common and often very distressing. Clinically it is often unclear if allergic contact dermatitis or irritant dermatitis is involved. In order to optimize therapy and prophylaxis, it is essential to identify relevant allergens or irritants. Data
Allergic contact dermatitis syndrome from bufexamac for nursing infant.
Tokio Nakada et al.
Dermatitis : contact, atopic, occupational, drug, 23(4), 185-186 (2012-07-26)
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