B0760
Bufexamac
analytical standard
Synonym(s):
2-(p-Butoxyphenyl)acetohydroxamic acid
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About This Item
Empirical Formula (Hill Notation):
C12H17NO3
CAS Number:
Molecular Weight:
223.27
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
219-451-1
MDL number:
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
CCCCOc1ccc(CC(=O)NO)cc1
InChI
1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
InChI key
MXJWRABVEGLYDG-UHFFFAOYSA-N
General description
Bufexamac is a drug with antipyretic, analgesic and anti-inflammatory properties.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Bufexamac may be used as a reference standard in the determination of bufexamac in pharmaceutical formulations using high-performance liquid chromatography (HPLC).
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Determination of bufexamac in cream and ointment by high-performance liquid chromatography.
Kamata K, et al.
Journal of Chromatography A, 370(3), 344-347 (1986)
A Schnuch et al.
Deutsche medizinische Wochenschrift (1946), 130(50), 2881-2886 (2005-12-13)
Bufexamac is a non-steroidal, anti-inflammatory drug used in the topical treatment of atopic dermatitis, stasis dermatitis and perianal eczema. The substance is known to cause severe allergic contact dermatitis (ACD) as an adverse effect (AE), which may be indistinguishable from
Katrin Kügler et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 3(12), 979-986 (2006-01-13)
Anogenital dermatoses (AGD) are common and often very distressing. Clinically it is often unclear if allergic contact dermatitis or irritant dermatitis is involved. In order to optimize therapy and prophylaxis, it is essential to identify relevant allergens or irritants. Data