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B0490000

Benzarone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134

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10 MG
$164.00

About This Item

Empirical Formula (Hill Notation):
C17H14O3
CAS Number:
1477-19-6
Molecular Weight:
266.29
MDL number:
MFCD00867417
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

benzarone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[o]1c2c(c(c1CC)C(=O)c3ccc(cc3)O)cccc2

InChI

1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

InChI key

RFRXIWQYSOIBDI-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Effect of anti-inflammatory agents on the glycosaminoglycan metabolism in cultured human synovial cells.
K Kleesiek et al.
Rheumatology international, 2(4), 167-174 (1982-01-01)
M L Hautekeete et al.
Liver, 15(1), 25-29 (1995-02-01)
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with
[Hepatitis caused by benzarone: a second case].
A Nakad et al.
Gastroenterologie clinique et biologique, 14(10), 782-784 (1990-01-01)
A Schmidt et al.
Arzneimittel-Forschung, 32(8), 810-815 (1982-01-01)
Rats of BD X strain and SHR/NIH Montreal Ingelheim strain (genetic hypertension) received a diet containing 3.9% cholesterol or 3.7% cholesterol plus 0.6% benzarone, respectively, and libitum for 5 or 9 months. The following chemical and ultrastructural results were obtained.
I Walter-Sack et al.
Klinische Wochenschrift, 66(4), 160-166 (1988-02-15)
Benzbromarone is one of the main uricosuric drugs currently used. We determined plasma concentrations of benzbromarone, bromobenzarone, and benzarone and 24 hour uric acid excretion in ten healthy individuals following fasting application of two different non-micronised benzbromarone brands. In addition
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