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A8251

Sigma-Aldrich

Acriflavine hydrochloride

Acriflavine hydrochloride

Powder

Synonym(s):

3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine

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$88.06
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10 G
$48.80
25 G
$88.06
100 G
$291.00

About This Item

CAS Number:
8063-24-9
Beilstein/REAXYS Number:
6265525
MDL number:
MFCD00069039
UNSPSC Code:
12171500
PubChem Substance ID:
24891216
NACRES:
NA.47

$48.80

Available to ship onMay 01, 2025Details

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Product Name

Acriflavine hydrochloride, fluorescent dye

Quality Level

200

form

powder

composition

Acriflavine HCL content, 10-50%
Proflavine HCL, 25-70%

technique(s)

microbe id | staining: suitable

color

faint brown to brown, and Orange to Dark Orange and Red to Very Dark Red

mp

260 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Cl-].Cl[H].Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1.C[n+]4c5cc(N)ccc5cc6ccc(N)cc46

InChI

1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

InChI key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

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Application

In living mice, acriflavine hydrochloride has been used in the confocal laser endomicroscopy to check the crypt structure in mucosa.[1] It has also been used in Neurospora strain selection by checking the acriflavine resistance.[2]

Biochem/physiol Actions

Acriflavine hydrochloride is a fluorescent dye. It is used as a topical contrast agent. It mainly stains nuclei and is applied to tissues before microscopy.[3]

Other Notes

A mixture of 3,6-diamino-10-methylacridinium (acriflavin) and 3,6-diaminoacridine (proflavin)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS6244
SHBS3673
SHBR5332
SHBR8114
SHBR3518

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period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock.
Emerson JM, et al.
Proceedings of the National Academy of Sciences of the USA, 112, 15707-15712 (2015)
Jian Yang et al.
Journal of the American Heart Association, 7(5) (2018-02-27)
Limb remote ischemic preconditioning (RIPC) protects against brain injury induced by stroke, but the underlying protective mechanisms remain unknown. As hypoxia inducible factor 1α (HIF-1α) is neuroprotective in stroke and mediates neuroinflammation, we tested the hypothesis that HIF-1α is a
Nashwa Amin et al.
Cells, 10(6) (2021-07-03)
Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes. In this study, we evaluated the role of HIF-1α in attenuating brain damage after endothelin-1 injection. Focal
Yang Hua et al.
Journal of AOAC International, 95(6), 1672-1688 (2013-03-05)
The Roka Listeria Detection Assay was compared to the reference culture methods for nine select foods and three select surfaces. The Roka method used Half-Fraser Broth for enrichment at 35 +/- 2 degrees C for 24-28 h. Comparison of Roka's
Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract.
Goetz M and Kiesslich R
Anticancer Research, 28, 353-360 (2008)
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