Albumin is a globular protein. Serum albumin is a member of the multigene protein family. Human serum albumin (HSA) consists of three homologous domains (I-III) that form a heart-shaped structure. Each domain is a result of two subdomains called A and B. Bovine serum albumin (BSA) has a structure that is very similar to HSA as it has a heart-shaped structure that has three homologous domains (I-III) and each domain has three sub-domains.
Application
Albumin from goat has been used to verify the specificity of radioimmunoassay (RIA)-780 and 805.
Biochem/physiol Actions
Albumin is a highly soluble, multifunctional and major circulating plasma protein. It plays a role in physiological and pharmacological areas. Albumin participates in the transport of metals, cholesterol, hormones, bile pigments, drugs, and fatty acids. It regulates osmotic pressure and distributes fluids between various compartments. In addition, plasma albumin exhibits anti-oxidant effects to minimize oxidative stress. Albumin attributes to the major portion of total serum antioxidant properties.
To determine whether a type of contrast medium (CM), iodixanol, modifies outer medullary descending vasa recta (DVR) vasoreactivity and nitric oxide (NO) production in isolated microperfused DVR. Animal handling conformed to the Animal Care Committee Guidelines of all participating institutions.
Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 484-494 (2015-11-19)
Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the drug-to-lipid ratio. A
Journal of biomedical optics, 20(5), 051015-051015 (2014-12-06)
The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assignments
Journal of biochemical and molecular toxicology, 29(8), 349-359 (2015-03-17)
Several reports indicated that histone deacetylases (HDACs) play a crucial role in inflammation and fibrogenesis. Sodium butyrate (SB) is a short-chain fatty acid having HDAC inhibition potential. The present study aimed to evaluate the protective effect of SB against L-arginine
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