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Biochem/physiol Actions
An NSAID that specifically potentiates the cytoxicity of anthracyclines (doxorubicin, daunorubicin and epirubium). Circumvents MRP-mediated multidrug resistance.
The aim of this trial was to compare acemetacin (ACE) with celecoxib (CEL) in terms of tolerability and efficacy in the treatment of osteoarthritis of the knee joint. A total of 105 patients (26-64 years old) suffering from primary osteoarthritis
Dose adjustments of NSAIDs according to body weight may be reasonable for an optimal efficacy/tolerance profile in the therapy of musculoskeletal disorders, but are unusual in adults. In this post hoc analysis of a prospective, one-arm clinical study of a
The structure of the title compound (systematic name: 2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid monohydrate, C(21)H(18)ClNO(6).H(2)O) contains one-dimensional infinite hydrogen-bonded chains. Molecules of acemetacin, a nonsteroidal anti-inflammatory drug, and water are linked by three independent O-H...O bonds. The central unit in each chain consists
Methods and findings in experimental and clinical pharmacology, 32(2), 101-105 (2010-04-20)
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of acute gout and inflammation. However, its use is limited due to side effects. Acemetacin is a prodrug of indomethacin that exhibits better gastric tolerability in preclinical and clinical
Se pu = Chinese journal of chromatography, 17(6), 586-587 (2003-01-30)
A method of HPLC for the quantitative determination of acemetacin and indometacin in human serum is described. After being extracted with diethyl ether, acemetacin and indometacin were analyzed by reversed-phase HPLC(Spherisorb-C8) and UV-detector(254 nm), with tolbutamide as internal standard. The
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