Structure-activity relationship of sphingosine-1-phosphate receptor agonists was examined. Cinnamyl derivative 1 was modified to improve S1P(1) agonistic activity as well as selectivity over S1P(3) agonistic activity. Dihydronaphthalene derivative 10d was identified as a potent S1P(1) receptor agonist with high selectivity
Skin pharmacology and physiology, 23(4), 213-224 (2010-05-01)
Allergic contact dermatitis is a complex syndrome and knowledge about the in vitro detection of small-molecular-weight compounds, particularly prohaptens, is limited. Therefore, we investigated chemical-induced gene expression changes in human antigen-presenting cells upon stimulation with immunogenic contact allergens, prohaptens and
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 43(6), 837-866 (2005-04-07)
A toxicologic and dermatologic review of cinnamyl alcohol when used as a fragrance ingredient is presented.
Journal of agricultural and food chemistry, 58(19), 10568-10575 (2010-09-22)
Coumarin is a flavoring which can cause hepatotoxicity in experimental animals and in a proportion of the human population. The tolerable daily intake (TDI) may be exceeded in consumers with high intake of cinnamon containing high levels of coumarin. The
The Journal of organic chemistry, 76(19), 7691-7698 (2011-08-05)
We report here the stereoconvergent formylation of (E/Z)-β-bromo-β-fluorostyrene mixtures with carbon monoxide and sodium formate catalyzed by palladium. Optimization of reaction conditions leads to the corresponding pure (Z)-α-fluorocinnamaldehydes in good yields. The reaction was extended to styrenes bearing electro-attracting or
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