1-(Trimethylsilyl)imidazole-Pyridine mixture is useful for derivatizing wet sugar samples, hindered hydroxyl groups in steroids and, in conjunction with fluorinated acylation reagents, amino acids. For moderately hindered or slowly reacting compounds, pyridine is an especially useful solvent for TMSI because of its ability to act as an HCl acceptor in silylation reactions involving organochlorosilanes.
Two new procedures for the gas-chromatographic analysis of monosaccharides are reported. One involves derivatization of the sugars by reaction with O-benzylhydroxylamine followed by trifluoroacetylation with N-methylbis(trifluoroacetamide) and chromatography on a DB-1701 capillary column. This technique probably provides the best resolution
Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs
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