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91018

Supelco

(S)-NIFE

≥98.0%

Synonym(s):

N-(4-Nitrophenoxycarbonyl)-L-phenylalanine 2-methoxyethyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H20N2O7
CAS Number:
328406-65-1
Molecular Weight:
388.37
MDL number:
MFCD04974576
UNSPSC Code:
12352200
PubChem Substance ID:
329769993

grade

derivatization grade ((chiral))

assay

≥98.0% (HPLC)
≥98.0%

form

powder

SMILES string

COCCOC(=O)[C@H](Cc1ccccc1)NC(=O)Oc2ccc(cc2)[N+]([O-])=O

InChI

1S/C19H20N2O7/c1-26-11-12-27-18(22)17(13-14-5-3-2-4-6-14)20-19(23)28-16-9-7-15(8-10-16)21(24)25/h2-10,17H,11-13H2,1H3,(H,20,23)/t17-/m0/s1

InChI key

ZSOUYIBYVUBOGT-KRWDZBQOSA-N

Other Notes

New chiral derivatizing agent for amino acid analysis by HPLC[1][2]; derivatization of secondary amino acids[3]

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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E. Olajos et al.
Chromatographia, 54, 77-77 (2001)
A. Peter et al.
Chromatographia, 52, 821-821 (2000)
Antal Péter et al.
Journal of chromatography. A, 948(1-2), 283-294 (2003-07-02)
A new chiral derivatizing agent, (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester, (S)-NIFE, was applied for the high-performance liquid chromatographic separation of enantiomers of 19 unnatural secondary amino acids: proline, pipecolic acid analogues, piperazine-2-carboxylic acid, morpholine-3-carboxylic acid, thiomorpholine-3-carboxylic acid and analogues containing the 1,2,3,4-tetrahydroisoquinoline
Sonika Sethi et al.
Biomedical chromatography : BMC, 34(1), e4730-e4730 (2019-10-28)
LC separation of biologically and pharmaceutically important enantiomers (from racemic or non-racemic mixtures) remains a subject of importance. The present review article deals with the liquid chromatographic enantioseparation of chiral selective serotonin reuptake inhibitors (SSRIs), namely citalopram, paroxetine, sertraline and
Zhe Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1058, 40-46 (2017-05-23)
There are significant differences in d-amino acid concentrations between healthy people and Alzheimer's disease patients. In order to investigate the potential correlation between d-amino acids and Alzheimer's disease, a simple and sensitive ultra high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
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