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909947

Sigma-Aldrich

3-Azido-L-alanine hydrochloride

≥95%

Synonym(s):

(S)-2-Amino-3-azidopropanoic acid hydrochloride, 3-Azido-L-alanine HCl, 3-Azido-L-alanine hydrochloride, H-L-Ala(N3)-OH*HCl, H-L-Aza-OH*HCl, H-L-Dap(N3)-OH*HCl

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About This Item

Empirical Formula (Hill Notation):
C3H6N4O2 · HCl
Molecular Weight:
166.57
UNSPSC Code:
12352209
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assay

≥95%

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

availability

available only in USA

storage temp.

2-8°C

Application

The in vivo incorporation of clickable unnatural amino acids such as 3-Azido-L-alanine with unique reactivity at a defined postition is used for functionalization of proteins. The azide functionalities in the protein can then be modified with almost any alkyne bearing molecule by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Copper-free alternatives with strained internal alkynes are also available (SPAAC). Some examples enabled with this technique are protein PEGylation, masking with sugars, and the attachment to antibodies.

pictograms

Flame
GHS02

signalword

Danger

hcodes

H242

Hazard Classifications

Self-react. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kristi L Kiick et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(1), 19-24 (2001-12-26)
The introduction of chemically unique groups into proteins by means of non-natural amino acids has numerous applications in protein engineering and functional studies. One method to achieve this involves the utilization of a non-natural amino acid by the cell's native

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