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90532

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N-Desisopropylpropranolol

analytical standard

Synonym(s):

(±)-1-Amino-3-(1-naphthyloxy)-2-propanol, (±)-Norpropranolol, N-Deisopropylpropranolol

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About This Item

Empirical Formula (Hill Notation):
C13H15NO2
CAS Number:
20862-11-7
Molecular Weight:
217.26
MDL number:
MFCD00526461
UNSPSC Code:
41116107
PubChem Substance ID:
329769920
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥97.5% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤1.0% water (calc. from elemental analysis)

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

NCC(O)COC1=CC=CC2=CC=CC=C21

InChI

1S/C13H15NO2/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,15H,8-9,14H2

InChI key

ZFMCITCRZXLMDJ-UHFFFAOYSA-N

General description

N-Desisopropylpropranolol is one of the active metabolites of propranolol, a widely prescribed β-adrenergic blocking drug for treating arrhythmias, thyrotoxicosis, angina pectoris, and hypertension.[1]

Application

N-Desisopropylpropranolol may be used as an analytical reference standard for the determination of the analyte in various biological samples[1][2][3][4] by chromatography techniques.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC3402
BCBV8575

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Versatile isocratic high-performance liquid chromatographic assay for propranolol and its basic, neutral and acidic metabolites in biological fluids
Kwong EC and Shen DD
Journal of Chromatography. B, Biomedical Sciences and Applications, 414(65), 365-379 (1987)
Development and validation of a capillary zone electrophoresis method for the determination of propranolol and N-desisopropylpropranolol in human urine
Nevado JJB, et al.
Analytica Chimica Acta, 559(1), 9-14 (2006)
An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations
He H, et al.
Royal Society of Chemistry Advances, 8(65), 37286-37294 (2018)
Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography
Harrison PM, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 343(1), 349-358 (1985)

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