905135
(±)-cis-N-Boc-2-fluorocyclohexylamine
≥95%
Synonym(s):
Monofluorinated ortho NBoc
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About This Item
Empirical Formula (Hill Notation):
C11H20FNO2
CAS Number:
Molecular Weight:
217.28
UNSPSC Code:
12352101
assay
≥95%
form
powder
storage temp.
2-8°C
Application
The incorporation of fluorine in agrochemical and pharmaceutical compounds is of high interest due to the ability to fine-tune the polarity, pKA-value, conformation and metabolic stability. Derived from a cis-selective hydrogenation developed by Glorius and coworkers, this fluorinated compound displays a diverse utility as a building block for chemical synthesis. Fluoro-cyclohexaneamine allows for the straightforward application in organic synthesis, after simple deprotection. It has been shown, that this compound can be used for the preparation of fluorinated analogs of Lomustine and Bromhexine.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mario P Wiesenfeldt et al.
Science (New York, N.Y.), 357(6354), 908-912 (2017-08-12)
All-cis-multifluorinated cycloalkanes exhibit intriguing electronic properties. In particular, they display extremely high dipole moments perpendicular to the aliphatic ring, making them highly desired motifs in material science. Very few such motifs have been prepared, as their syntheses require multistep sequences
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