81162

Poly(ethylene glycol)

tested according to Ph. Eur., 300

• Synonym(s): Macrogol 300, Polyoxyethylene, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 12352104
• PubChem Substance ID: 24887667
• NACRES: NA.21

Properties

• agency: tested according to Ph. Eur.
• Quality Level: 100
• form: liquid
• mol wt: M_r 285-315
• pH: 6-7 (23 °C, at 10 g/l)
• application(s): pharmaceutical (small molecule)
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Poly(ethylene glycol) (PEG) is a linear polyether of ethylene glycol (ethane-1,2-diol).[1] This non-ionic polymer[2] is soluble in water, benzene, ethanol, acetonitrile, and dichloromethane. It is insoluble in diethyl ether and hexane.[3] It usually exists in the monomer and aqueous phases.[4]

Application

Poly(ethylene glycol) has been used:

• to dissolve NEO2734 (BET and CBP/EP300 inhibitor) for drug efficacy studies in vivo[5]
• as a drug carrier for histone deacetylase (HDAC) inhibitor ACY-1215[6]
• to study the effects of drug-induced peripheral neuropathy[7]

Biochem/physiol Actions

Poly(ethylene glycol) (PEG) is used in various pharmaceutical applications.[3] This polymer occurs as a preservative and is used in biomedical applications like drug delivery systems, biosensing, and tissue engineering. PEG is also used in cosmetic ointments and creams. It is used as a binding and dispersing agent in chemical and other industries.[8]

Features and Benefits

• Environment friendly[4]
• Biocompatible[4]
• Unique solvent solution[4]

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 428.0 °F - closed cup
• flash_point_c: 220.00 °C - closed cup
• ppe: Eyeshields, Gloves