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77624

Sigma-Aldrich

Dexpanthenol

tested according to Ph. Eur.

Synonym(s):

D-Panthenol, Dexpanthenolum, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B

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About This Item

Empirical Formula (Hill Notation):
C9H19NO4
CAS Number:
81-13-0
Molecular Weight:
205.25
Beilstein/REAXYS Number:
1724947
EC Number:
201-327-3
MDL number:
MFCD00065006
UNSPSC Code:
12352209
PubChem Substance ID:
329767823

biological source

synthetic

agency

USP/NF
tested according to Ph. Eur.

assay

98.0-101.0% anhydrous basis

form

viscous liquid (clear)

color

colorless

density

1.20 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCCO

InChI

1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1

InChI key

SNPLKNRPJHDVJA-ZETCQYMHSA-N

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT8265
BCBR3503V
BCBQ1802V

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M Göbbels et al.
Klinische Monatsblatter fur Augenheilkunde, 209(2-3), 84-88 (1996-08-01)
In this controlled, randomized, double-masked study the effect of dexpanthenol-containing artificial tears (Siccaprotect) on patients with dry eyes was examined. 50 patients applied either dexpanthenol-containing artificial tears (Siccaprotect) or the identical, but free of dexpanthenol, eye drops five times daily
M Sachs et al.
Zeitschrift fur Ernahrungswissenschaft, 29(4), 270-283 (1990-12-01)
The aim of this study was the examination of the metabolism and mechanism of action of D-pantothenyl alcohol in patients with postoperative intestinal atony. Seven metabolically healthy patients were examined on the 4th day following colorectal surgery, before bowel activity
W Gehring et al.
Arzneimittel-Forschung, 50(7), 659-663 (2000-08-31)
In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal
Fritz Ebner et al.
American journal of clinical dermatology, 3(6), 427-433 (2002-07-13)
Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid
Sonja Heinzelmann et al.
The British journal of ophthalmology, 99(1), 98-102 (2014-08-21)
To determine the incidence and potential risk factors of cystoid macular oedema (CMO) following Descemet membrane endothelial keratoplasty (DMEK) with or without simultaneous cataract surgery. In this study, 155 eyes of 88 patients suffering from Fuchs endothelial dystrophy (81%), bullous
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