75182

Isoniazid

certified reference material, TraceCERT^®

• Synonym(s): 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Empirical Formula (Hill Notation): C₆H₇N₃O
• CAS Number: 54-85-3
• Molecular Weight: 137.14
• Beilstein/REAXYS Number: 119374
• EC Number: 200-214-6
• MDL number: MFCD00006426
• UNSPSC Code: 12352200
• PubChem Substance ID: 329766241
• NACRES: NA.24

Properties

• grade: certified reference material; TraceCERT^®
• product line: TraceCERT^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): gas chromatography (GC): suitable
• mp: 171-173 °C (lit.)
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• SMILES string: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Description

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Recommended products

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Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Oral - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3