673277

2-Methyltetrahydrofuran

BioRenewable, anhydrous, ≥99%, Inhibitor-free

• Synonym(s): 2-MeTHF, Tetrahydro-2-methylfuran, Tetrahydrosilvan
• Empirical Formula (Hill Notation): C₅H₁₀O
• CAS Number: 96-47-9
• Molecular Weight: 86.13
• Beilstein/REAXYS Number: 102448
• EC Number: 202-507-4
• MDL number: MFCD00005367
• UNSPSC Code: 12352005
• PubChem Substance ID: 57652076
• NACRES: NA.21

Properties

• grade: anhydrous
• Quality Level: 100
• assay: ≥99%
• form: liquid
• expl. lim.: 0.34-6.3 % (lit.)
• greener alternative product characteristics: Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• impurities: ≤0.002% water; ≤0.005% water (100 mL pkg)
• evapn. residue: ≤0.0003%
• refractive index: n20/D 1.406 (lit.)
• bp: 78-80 °C (lit.)
• mp: -136 °C (lit.)
• density: 0.86 g/mL at 25 °C (lit.)
• greener alternative category: , Aligned, Aligned
• SMILES string: CC1CCCO1
• InChI: 1S/C5H10O/c1-5-3-2-4-6-5/h5H,2-4H2,1H3
• InChI key: JWUJQDFVADABEY-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks". Click here for more information.
2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahydrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.

application

2-Methyltetrahydrofuran may be used as a solvent for phosphatidylserine synthesis.
It may be used as an alternative solvent to:

• Dimethyl sulfoxide (DMSO) or methyl tert-butyl ether (MTBE) in the C-C bond forming reactions catalyzed by lyase enzyme.
• Tetrahydrofuran (THF) in the reaction between Grignard reagents and carbonyl compounds.
• Methylene chloride in some biphasic reactions.

Green Alternatives to DCM and THF from Renewable Resources

Organic Solar Cells

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

Features and Benefits

Greener alternative for THF, DCM, DMSO, and MTBE

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302,H315,H318
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 14.0 °F - closed cup
• flash_point_c: -10.0 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter