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61382

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D-α-Hydroxyglutaric acid disodium salt

analytical standard

Synonym(s):

D-2HG, (R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

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About This Item

Linear Formula:
C5H6O5Na2
CAS Number:
103404-90-6
Molecular Weight:
192.08
Beilstein/REAXYS Number:
5318041
MDL number:
MFCD00069573
UNSPSC Code:
41116107

grade

analytical standard

assay

≥98.0% (GC)

optical activity

[α]/D 8.5±1.5°, c = 1 in 0.1 M NaOH

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI key

DZHFTEDSQFPDPP-HWYNEVGZSA-L

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Application

D-α-Hydroxyglutaric acid disodium salt may be used as an analytical standard for the quantification of 2-hydroxyglutarate (2HG)[1] and 2-hydroxyglutarate (2HG) enantiomers[2] in human serum samples of patients with isocitrate dehydrogenase (IDH) mutated tumors using chromatography-based techniques.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG1562
BCCF1681
BCBZ4749

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Measurement of 2-hydroxyglutarate enantiomers in serum by chiral gas chromatography-tandem mass spectrometry and its application as a biomarker for IDH mutant gliomas
Strain KS, et al.
Clinical mass spectrometry, 15, 16-25 (2020)
Validation of a routine gas chromatography mass spectrometry method for 2-hydroxyglutarate quantification in human serum as a screening tool for detection of idh mutations
Fernandez-Galan E, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1083, 28-34 (2018)

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